CRIPT (CXXC repeat containing interactor of PDZ3 domain) is a multifunctional protein with critical roles in RNA splicing and neuronal development. As a component of the minor spliceosome, CRIPT stabilizes U12 snRNP and is involved in splicing U12-type introns in pre-mRNAs 1. In neuronal contexts, CRIPT serves as a binding partner for SAP97's PDZ3 domain and promotes dendrite growth in mammalian spinal cord neurons, localizing to synapses with GluA1 and SAP97 along the dendritic tree 2. The protein also plays an essential role in mitotic spindle disassembly through redox-dependent mechanisms, directly interacting with tubulin subunits via cysteine residue modifications to induce microtubule depolymerization 3. Biallelic mutations in CRIPT cause Rothmund-Thomson-like syndrome (RTS3), characterized by poikiloderma, short stature, dysmorphic features, neurodevelopmental delay, and seizures 4. CRIPT-deficient cells exhibit increased cellular senescence markers, suggesting this contributes to the premature aging phenotype 4. The diverse clinical manifestations, ranging from primordial dwarfism to complex syndromic features, highlight CRIPT's importance in multiple cellular processes including RNA processing, cytoskeletal organization, and cell cycle regulation 5.