CRISP3 (cysteine-rich secretory protein 3) is a secreted immunoregulatory protein with diverse functions across multiple physiological systems. The protein contains eight disulfide bonds and exists in both glycosylated and non-glycosylated forms 1. CRISP3 functions as a biomarker for immune responses, being significantly upregulated in sepsis patients and serving as a superior predictive biomarker compared to traditional inflammatory markers like C-reactive protein and procalcitonin 2. In reproductive tissues, CRISP3 localizes to endometrial epithelium and is regulated throughout menstrual cycles, where it facilitates epithelial cell adhesion and proliferation, suggesting roles in endometrial repair and regeneration 3. The protein also regulates male fertility through microRNA-mediated mechanisms affecting sperm motility and morphology 4. In cancer pathogenesis, CRISP3 promotes tumor progression through multiple mechanisms: it enhances prostate cancer cell invasion by modifying cell-cell adhesion proteins like LASP1 and TJP1 5, and its expression is androgen receptor-dependent and epigenetically regulated 6. Additionally, CRISP3 forms complexes with PSP94 to regulate P2RX7-mediated inflammatory signaling through CITED2, influencing tumor immune microenvironments 7. CRISP3 also serves as a prognostic biomarker in breast cancer, promoting malignant phenotypes under hypoxic conditions via IL-17/AKT signaling 8.