1 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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5PubMed Papers
7Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingdefense responseinnate immune responseresponse to other organismgastric canceratrial fibrillationintellectual developmental disorder, X-linked 110chronic obstructive pulmonary disease
Based on limited published evidence, DEFB108B encodes a defensin with antibacterial activity and protein binding capability. The gene has been identified as significantly associated with gastric cancer risk through genome-wide association studies in a Korean population, with DEFB108B showing the lowest p-value (5.94×10⁻¹⁵) among prioritized genes 1. However, the mechanistic role of DEFB108B in gastric cancer pathogenesis remains unclear and requires further investigation.
1
DEFB108B identified with strongest gene-based association with gastric cancer risk (p=5.94×10⁻¹⁵) in Korean GWAS study
PMID: 37340842⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
gastric cancerOpen Targets
atrial fibrillationOpen Targets
intellectual developmental disorder, X-linked 110Open Targets
chronic obstructive pulmonary diseaseOpen Targets
male infertilityOpen Targets
acute myeloid leukemiaOpen Targets
No pathogenic variants reported on ClinVar for this gene.