Based on limited published evidence, DEFB108B encodes a defensin with antibacterial activity and protein binding capability. The gene has been identified as significantly associated with gastric cancer risk through genome-wide association studies in a Korean population, with DEFB108B showing the lowest p-value (5.94×10⁻¹⁵) among prioritized genes 1. However, the mechanistic role of DEFB108B in gastric cancer pathogenesis remains unclear and requires further investigation.