CYFIP1 (cytoplasmic FMR1 interacting protein 1) is a multifunctional protein that plays critical roles in both translational regulation and cytoskeletal dynamics. CYFIP1 forms part of the CYFIP1-EIF4E-FMR1 complex that binds to mRNA caps and mediates translational repression, acting as an adapter between EIF4E and FMR1 to promote FMR1's translation repression activity in the brain 1. Additionally, CYFIP1 participates in the WAVE complex that regulates actin filament reorganization through interaction with the Arp2/3 complex, controlling membrane ruffles, lamellipodia formation, and axon outgrowth 2. The protein is crucial for microglial function, specifically synaptic engulfment, as CYFIP1 knockout in human microglia-like cells significantly reduces synaptic vesicle phagocytosis and alters cell morphology toward a more ramified profile 2. CYFIP1 is located in the 15q11.2 BP1-BP2 chr15 region, and deletions affecting this gene contribute to neurodevelopmental disorders including Prader-Willi syndrome, autism spectrum disorders, schizophrenia, and epilepsy 34. Loss of CYFIP1 function leads to dysregulation of schizophrenia and epilepsy gene networks, compromises cytoskeletal remodeling, and affects FMRP targets and postsynaptic density genes 5. The gene also contributes to mitochondrial dysfunction and altered GABAergic signaling, potentially underlying social behavioral deficits associated with autism and schizophrenia 6.