DCAF13 (DDB1 and CUL4 associated factor 13) is a substrate-recognition component of the CRL4 E3 ubiquitin ligase complex with diverse oncogenic functions across multiple cancer types. As a nucleolar protein, DCAF13 promotes ribosome biogenesis by facilitating rDNA transcription through direct interaction with TAF1A, a component of the RNA polymerase I preinitiation complex 1. The protein also enhances Pol I transcription activity by promoting K63-linked ubiquitination of RPA194, stimulating global protein synthesis and cell growth 2. Beyond ribosomal functions, DCAF13 acts as an oncogene by targeting tumor suppressors for degradation, including p53 through K48-linked ubiquitination in lung adenocarcinoma 3 and FRAS1 to activate FAK signaling in ovarian cancer 4. DCAF13 also mediates DNA repair by recognizing TOP1 DNA-protein crosslinks for proteasomal degradation 5. In reproductive biology, DCAF13 is essential for decidualization and normal pregnancy, with deficiency linked to preeclampsia pathogenesis 6. Clinically, DCAF13 is overexpressed in multiple cancers including breast, lung, and ovarian cancers, correlating with poor prognosis and enhanced metastatic potential 741. Notably, chemotherapy with doxorubicin increases DCAF13 expression, potentially promoting drug-resistant cancer cell migration 7.