DCAF6 (DDB1 and CUL4 associated factor 6) functions as a substrate receptor for the CRL4-DDB1 E3 ubiquitin ligase complex and serves as a ligand-dependent coactivator of nuclear receptors. As a component of the CRL4DCAF6 E3 ligase, DCAF6 facilitates the ubiquitination and degradation of specific target proteins, including CtBP1/2 transcriptional corepressors 1 and PPP2R1B, a scaffold subunit of protein phosphatase 2A 2. This ubiquitin ligase activity plays critical roles in cellular processes including apoptosis regulation during intervertebral disc degeneration 1. DCAF6 also functions in cardiac physiology, where it interacts with α-actinin 2 at the Z-disc to maintain sarcomere structure and facilitates F-actin bundling 3. Deficiency of DCAF6 leads to cardiomyopathy through disrupted sarcomere organization and impaired mitochondrial respiration 3. Additionally, DCAF6 is essential for spermatogenesis, as its disruption through the CRL4DCAF6 complex affects meiotic processes 2. Mutations in DCAF6 have been identified as potential genetic causes of cerebral visual impairment 4. The protein's diverse functions highlight its importance in maintaining cellular homeostasis across multiple tissue types.