DCDC1 (doublecortin domain containing 1) is a microtubule-binding protein located on chromosome 11 that plays important roles in cellular transport and development 1. The protein contains a doublecortin domain that enables microtubule binding and polymerization functions 1. DCDC1 mediates dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis, indicating a crucial role in cell division 2. The gene shows tissue-specific expression patterns, with high expression in adult testis and notably higher expression in fetal brain compared to adult brain 1. DCDC1 has clinical significance in several disease contexts. Deletions involving DCDC1 in the 11p13 region have been associated with aniridia, a rare eye disorder characterized by iris hypoplasia 345. Interestingly, homozygous DCDC1 deletions can cause isolated aniridia even without affecting the nearby PAX6 gene, suggesting independent pathogenic mechanisms 6. DCDC1 mutations have also been identified as significantly mutated in various cancers including gastric linitis plastica and esophageal squamous cell carcinoma 78. These findings indicate DCDC1's importance in both developmental processes and disease pathogenesis, though the precise mechanisms linking DCDC1 dysfunction to these conditions require further investigation.