Based on limited published evidence, DEFB113 (defensin beta 113) is an antimicrobial peptide with antibacterial activity. DEFB113 is expressed in gingival tissues as part of the innate immune defense at mucosal sites 1. The gene shows age-related variations in expression levels in healthy gingival tissues and altered expression in periodontal disease states 1. DEFB113 contributes to the epithelial barrier's antimicrobial factor complement, supporting innate immunity at oral mucosal sites.