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GeneE
0 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
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DEFB131A
defensin beta 131A
Chromosome 4 Β· 4p16.1
NCBI Gene: 644414Ensembl: ENSG00000186146.2HGNC: HGNC:18108UniProt: P59861
8PubMed Papers
14Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
protein bindingGO:0005615innate immune responseextracellular regiontransient ischemic attackopioid use disorderalcohol drinkingdeafness
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

defensin beta 131A

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜14
transient ischemic attackOpen Targets
0.11Weak
opioid use disorderOpen Targets
0.09Suggestive
alcohol drinkingOpen Targets
0.05Suggestive
deafnessOpen Targets
0.05Suggestive
autosomal recessive nonsyndromic hearing loss 9Open Targets
0.04Suggestive
goutOpen Targets
0.04Suggestive
autosomal dominant nonsyndromic hearing lossOpen Targets
0.04Suggestive
placenta praeviaOpen Targets
0.03Suggestive
hearing loss, autosomal recessiveOpen Targets
0.03Suggestive
mouth neoplasmOpen Targets
0.03Suggestive
intestinal infectious diseaseOpen Targets
0.03Suggestive
pneumonitisOpen Targets
0.02Suggestive
HepatitisOpen Targets
0.00Suggestive
bacterial diseaseOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
PPP1R14BShared pathway100%BSPRYShared pathway100%ANKHD1Shared pathway100%CYBC1Shared pathway100%TRIM50Shared pathway100%TRIML2Shared pathway100%
Tissue Expression6 tissues
Heart
0%
Lung
0%
Brain
0%
Bone Marrow
0%
Ovary
0%
Liver
0%
Gene Interaction Network
Click a node to explore
DEFB131APPP1R14BBSPRYANKHD1CYBC1TRIM50TRIML2
PROTEIN STRUCTURE
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AlphaFoldAI-predicted Β· UniProt P59861
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.91LoF Tolerant
pLIβ“˜
0.03Tolerant
Observed/Expected LoF1.27 [0.51–1.91]
RankingsWhere DEFB131A stands among ~20K protein-coding genes
  • #17,572of 20,598
    Most Researched8
  • #17,321of 17,882
    Most Constrained (LOEUF)1.91
Genes detectedDEFB131A
Sources retrieved0 papers
Response timeβ€”