DEFB131A | GeneE

5 sources retrieved · Most recent: April 2026 · Index updated 3 months ago

8PubMed Papers

#17,741 · top 91% of 19K genes

14Diseases

top 93%

0Drugs

0Pathogenic Variants

Experimental GO EvidenceSwiss-Prot Reviewed

protein bindingGO:0005615innate immune responseextracellular regiontransient ischemic attackopioid use disorderalcohol drinkingdeafness

AI Summary

AI summary not yet available. Showing NCBI Gene summary.

defensin beta 131A

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.

Disease Associations14

transient ischemic attackOpen Targets

0.11Weak

opioid use disorderOpen Targets

0.09Suggestive

alcohol drinkingOpen Targets

0.05Suggestive

deafnessOpen Targets

0.05Suggestive

autosomal recessive nonsyndromic hearing loss 9Open Targets

0.04Suggestive

goutOpen Targets

0.04Suggestive

autosomal dominant nonsyndromic hearing lossOpen Targets

0.04Suggestive

placenta praeviaOpen Targets

0.03Suggestive

hearing loss, autosomal recessiveOpen Targets

0.03Suggestive

mouth neoplasmOpen Targets

0.03Suggestive

intestinal infectious diseaseOpen Targets

0.03Suggestive

pneumonitisOpen Targets

0.02Suggestive

HepatitisOpen Targets

0.00Suggestive

bacterial diseaseOpen Targets

0.00Suggestive

Pathogenic Variants

No pathogenic variants reported on ClinVar for this gene.

Related Genes

No related genes found for this gene.

Tissue Expression

No tissue expression data available for this gene.

Gene Interaction Network

No interaction data available for this gene.

StructureAlphaFold

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AlphaFoldAI-predicted · UniProt P59861

View on AlphaFold

ConstraintgnomAD v4.1

LOEUFⓘ

1.91LoF Tolerant

pLIⓘ

0.03Tolerant

Observed/Expected LoF1.27 [0.51–1.91]

Rankings2 dim

Where DEFB131A stands among ~20K protein-coding genes

#17,572of 20,598
Most Researched8
#17,321of 17,882
Most Constrained (LOEUF)1.91

Meta

Genes detectedDEFB131A

Sources retrieved5 papers

Response time—

Sources5

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.

PMID: 21873635

Brief Bioinform · 2011

0.95

Genome-scale RNAi screen for host factors required for HIV replication.

PMID: 18976975

Cell Host Microbe · 2008

0.95

Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.

PMID: 16033865

Physiol Genomics · 2005

0.95

ORFeome-based search of airway epithelial cell-specific novel human [beta]-defensin genes.

PMID: 12600824

Am J Respir Cell Mol Biol · 2003

0.95

Discovery of five conserved beta -defensin gene clusters using a computational search strategy.

PMID: 11854508

Proc Natl Acad Sci U S A · 2002

0.95

View all 8 papers on PubMed →

Loading gene record…

5 sources retrieved · Most recent: April 2026 · Index updated 3 months ago

8PubMed Papers

#17,741 · top 91% of 19K genes

14Diseases

top 93%

0Drugs

0Pathogenic Variants

Experimental GO EvidenceSwiss-Prot Reviewed

protein bindingGO:0005615innate immune responseextracellular regiontransient ischemic attackopioid use disorderalcohol drinkingdeafness

AI Summary

AI summary not yet available. Showing NCBI Gene summary.

defensin beta 131A

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.

Disease Associations14

transient ischemic attackOpen Targets

0.11Weak

opioid use disorderOpen Targets

0.09Suggestive

alcohol drinkingOpen Targets

0.05Suggestive

deafnessOpen Targets

0.05Suggestive

autosomal recessive nonsyndromic hearing loss 9Open Targets

0.04Suggestive

goutOpen Targets

0.04Suggestive

autosomal dominant nonsyndromic hearing lossOpen Targets

0.04Suggestive

placenta praeviaOpen Targets

0.03Suggestive

hearing loss, autosomal recessiveOpen Targets

0.03Suggestive

mouth neoplasmOpen Targets

0.03Suggestive

intestinal infectious diseaseOpen Targets

0.03Suggestive

pneumonitisOpen Targets

0.02Suggestive

HepatitisOpen Targets

0.00Suggestive

bacterial diseaseOpen Targets

0.00Suggestive

Pathogenic Variants

No pathogenic variants reported on ClinVar for this gene.

Related Genes

No related genes found for this gene.

Tissue Expression

No tissue expression data available for this gene.

Gene Interaction Network

No interaction data available for this gene.

StructureAlphaFold

Preparing viewer…

AlphaFoldAI-predicted · UniProt P59861

View on AlphaFold

ConstraintgnomAD v4.1

LOEUFⓘ

1.91LoF Tolerant

pLIⓘ

0.03Tolerant

Observed/Expected LoF1.27 [0.51–1.91]

Rankings2 dim

Where DEFB131A stands among ~20K protein-coding genes

#17,572of 20,598
Most Researched8
#17,321of 17,882
Most Constrained (LOEUF)1.91