Based on limited published evidence, DEFB134 encodes a defensin with antibacterial activity. The gene is located in the 8p23.1 region, where it was identified in a larger deletion associated with congenital diaphragmatic hernia and cardiac defects 1. Additionally, DEFB134 shows notable copy number variations (CNVs) with high gene copy numbers in patients experiencing ventricular fibrillation during ST-elevation acute myocardial infarction, suggesting potential involvement in cardiac pathology 2. However, direct functional studies on DEFB134 are limited.