DISP2 (dispatched RND transporter family member 2) is a plasma membrane-localized protein that functions as an RND transporter involved in hedgehog signaling pathway regulation 1. DISP2 is prominently expressed in neuronal cells throughout the central and enteric nervous systems, localizing to neuronal soma and processes 2. As a dispatched homolog, DISP2 is implicated in the release of lipid-anchored hedgehog signaling molecules from producing cells, similar to DISP1 3. DISP2 has documented roles in pancreatic islet development and serves as a useful cell surface marker for immunoisolation of beta cells and their progenitors via FACS-mediated purification 4. Recent phosphoproteomic analysis identified DISP2 as an ATM/ATR substrate kinase target involved in neurite extension and microtubule dynamics, with dysregulation contributing to neural atrophy through growth cone collapse 5. Clinically, DISP2 expression is downregulated in low-grade glioma tissue compared to normal brain, with low DISP2 expression serving as a protective factor associated with improved prognosis 6. A hypermutable (CCG) repeat region in DISP2's 5' untranslated region shows association with late-onset neurocognitive disorders, particularly Alzheimer's disease and vascular dementia, with disease-associated genotypes displaying extreme short alleles (5-6 repeats) absent in healthy controls 7. DISP2 variants have been identified in genome-wide association studies of colonic diverticulosis susceptibility 8.