1 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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11PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
dynein light chain bindingdynein heavy chain bindingcilium movementaxonemal dynein complex assemblyCOVID-19ulcerative colitisallergic rhinitispsoriasis vulgaris
DNAI4 encodes a dynein axonemal intermediate chain essential for assembling the axonemal dynein complex, which powers ciliary and flagellar motility. Based on limited published evidence, DNAI4 functions as an interaction partner within the sperm motility machinery alongside heavy and light chain dyneins 1. The protein localizes to axonemal dynein particles and binds dynein heavy and light chains, supporting axoneme structure and function.
1
DNAI4 interacts with dynein heavy chains and other axonemal proteins involved in sperm flagellar motility machinery
PMID: 38874855⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
ulcerative colitisOpen Targets
allergic rhinitisOpen Targets
psoriasis vulgarisOpen Targets
allergic diseaseOpen Targets
respiratory system diseaseOpen Targets
deep vein thrombosisOpen Targets
Abnormal thrombosisOpen Targets
benign colon neoplasmOpen Targets
Eczematoid dermatitisOpen Targets
partial chromosome Y deletionOpen Targets
inflammatory bowel diseaseOpen Targets
Male infertility with spermatogenesis disorder due to single gene mutationOpen Targets
hemoglobin D diseaseOpen Targets
spermatogenic failure 55Open Targets
spermatogenic failure 62Open Targets
spermatogenic failure 88Open Targets
No pathogenic variants reported on ClinVar for this gene.