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GeneE
10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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DPT
dermatopontin
Chromosome 1 · 1q24.2
NCBI Gene: 1805Ensembl: ENSG00000143196.6HGNC: HGNC:3011UniProt: Q07507
43PubMed Papers
20Diseases
0Drugs
1Pathogenic Variants
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
extracellular matrixprotein bindingGO:0005615extracellular matrix structural constituenthypothyroidismSensorineural hearing impairmenthearing lossatrial fibrillation
✦AI Summary

Based on the provided abstracts, there is insufficient information to write a comprehensive gene function summary for DPT (dermatopontin). The provided PubMed abstracts do not contain research specifically investigating the DPT gene or dermatopontin protein function. The abstracts discuss unrelated topics including drug provocation testing 12, deoxypodophyllotoxin (DPT compound) effects on glioma cells 34, asbestos-related diffuse pleural thickening 5, poliovirus vaccination 6, cataracts 7, and temperature effects on male infertility 8. None of these studies examine dermatopontin's role in extracellular matrix organization, integrin binding, TGF-β1 enhancement, collagen fibril formation, or cell proliferation inhibition as described in the UniProt annotation. To provide an accurate evidence-based summary of DPT gene function, relevant studies specifically investigating dermatopontin protein would be required.

Sources cited
1
Discusses drug provocation testing, not dermatopontin gene function
PMID: 38155501
2
Studies deoxypodophyllotoxin compound effects on glioma cells, not dermatopontin protein
PMID: 37277492
3
Examines asbestos-related diffuse pleural thickening, not dermatopontin gene
PMID: 25171783
4
Investigates deoxypodophyllotoxin-induced cell death pathways, not dermatopontin function
PMID: 37186123
5
Focuses on poliovirus vaccination, not dermatopontin gene research
PMID: 21922761
6
Studies cortical cataracts and refractive error, not dermatopontin protein
PMID: 30921809
7
Reviews drug provocation testing methodology, not dermatopontin gene function
PMID: 28677662
8
Examines temperature effects on male infertility, not dermatopontin research
PMID: 40361043
Disease Associationsⓘ20
hypothyroidismOpen Targets
0.40Moderate
Sensorineural hearing impairmentOpen Targets
0.40Moderate
hearing lossOpen Targets
0.39Weak
atrial fibrillationOpen Targets
0.36Weak
COVID-19Open Targets
0.35Weak
severe acute respiratory syndromeOpen Targets
0.35Weak
Progressive sensorineural hearing impairmentOpen Targets
0.34Weak
deep vein thrombosisOpen Targets
0.34Weak
restless legs syndromeOpen Targets
0.33Weak
phobic disorderOpen Targets
0.31Weak
septic shockOpen Targets
0.31Weak
blood coagulation diseaseOpen Targets
0.29Weak
lower respiratory tract diseaseOpen Targets
0.27Weak
placenta praeviaOpen Targets
0.26Weak
venous thromboembolismOpen Targets
0.25Weak
pulmonary embolismOpen Targets
0.24Weak
PhlebitisOpen Targets
0.22Weak
ThrombophlebitisOpen Targets
0.22Weak
central nervous system infectionOpen Targets
0.21Weak
polycythemia veraOpen Targets
0.21Weak
Pathogenic Variants1
NM_001937.5(DPT):c.544C>T (p.Arg182Cys)Pathogenic
Progressive sensorineural hearing impairment
★☆☆☆2016→ Residue 182
View on ClinVar ↗
Related Genes
LOXL4Shared pathway100%COLGALT1Shared pathway100%COLGALT2Shared pathway100%P4HA1Shared pathway100%FMODShared pathway100%LUMProtein interaction98%
Tissue Expression6 tissues
Heart
100%
Lung
38%
Liver
16%
Ovary
9%
Brain
1%
Bone Marrow
0%
Gene Interaction Network
Click a node to explore
DPTLOXL4COLGALT1COLGALT2P4HA1FMODLUM
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted · UniProt Q07507
View on AlphaFold ↗
Constraintⓘ
LOEUFⓘ
0.96LoF Tolerant
pLIⓘ
0.00Tolerant
Observed/Expected LoF0.67 [0.47–0.96]
RankingsWhere DPT stands among ~20K protein-coding genes
  • #9,719of 20,598
    Most Researched43
  • #5,141of 5,498
    Most Pathogenic Variants1
  • #9,103of 17,882
    Most Constrained (LOEUF)0.96
Genes detectedDPT
Sources retrieved10 papers
Response time—
📄 Sources
10â–¼
1
EAACI/ENDA position paper on drug provocation testing.
PMID: 38155501
Allergy · 2024
1.00
2
Activated SIRT1 contributes to DPT-induced glioma cell parthanatos by upregulation of NOX2 and NAT10.
PMID: 37277492
Acta Pharmacol Sin · 2023
0.90
3
Asbestos-related diffuse pleural thickening.
PMID: 25171783
Respiration · 2014
0.80
4
TAX1BP1 contributes to deoxypodophyllotoxin-induced glioma cell parthanatos via inducing nuclear translocation of AIF by activation of mitochondrial respiratory chain complex I.
PMID: 37186123
Acta Pharmacol Sin · 2023
0.70
5
[Inactivated poliovirus vaccine].
PMID: 21922761
Nihon Rinsho · 2011
0.60