DRC7 (dynein regulatory complex subunit 7) is an essential component of the nexin-dynein regulatory complex (N-DRC), a critical structural assembly located between doublet microtubules in motile cilia and flagella 1. DRC7 functions as a key regulator of ciliary and flagellar motility by maintaining axonemal alignment and integrity and regulating microtubule sliding 1. The protein is required for proper incorporation of other N-DRC components into the flagellum; without DRC7, the axoneme becomes disorganized and the characteristic '9+2' microtubule arrangement cannot be maintained 1. DRC7 is essential for male fertility and spermatogenesis. Drc7 knockout male mice are infertile, producing short immotile spermatozoa due to defective flagellar assembly 1. At the systemic level, core N-DRC components including DRC7 are crucial for survival on pure genetic backgrounds and impair motile cilia function and flagellar axoneme stability 2. DRC7 mutations are associated with male infertility phenotypes, particularly azoospermia 3, and genetic variants in DRC7 are identified in infertile male cohorts 4. The gene is identified as a key biomarker for non-obstructive azoospermia diagnosis and treatment 5. DRC7 defects contribute to primary ciliary dyskinesia symptoms including male infertility, making it a candidate for inclusion in male infertility genetic screening panels.