DRG1 (developmentally regulated GTP binding protein 1) is a highly conserved GTPase that plays critical roles in protein translation and cellular development. The protein catalyzes GTP hydrolysis to GDP, with its intrinsic GTPase activity being stimulated by ZC3H15/DFRP1 binding 1. DRG1 functions as a translation factor, with hydroxylation at lysine-22 by JMJD7 enabling RNA binding and translational regulation 2. Beyond translation, DRG1 binds microtubules and promotes their polymerization and stability, which is essential for mitotic spindle assembly during cell division, independent of its GTPase activity 3. DRG1 exhibits tumor suppressor properties, with low expression levels associated with breast cancer metastasis and poor survival outcomes 4. Loss-of-function mutations in DRG1 cause Tan-Almurshedi syndrome, a recessive neurodevelopmental disorder characterized by global developmental delay, primary microcephaly, short stature, and craniofacial anomalies 1. The protein's evolutionary conservation from sponges to humans, along with mouse knockout studies showing preweaning lethality, underscores its fundamental importance in cellular processes and mammalian development 31.