DRG2 (developmentally regulated GTP-binding protein 2) is a conserved GTPase that plays multiple regulatory roles in cellular processes. As a GTP-binding protein, DRG2 catalyzes GTP hydrolysis and localizes to both cytoplasm and nucleus 1. The protein regulates membrane trafficking, particularly in endosomal recycling pathways, where it stabilizes Rac1-positive membrane tubules required for transferrin recycling 2. DRG2 also controls microtubule dynamics and Golgi organization through GSK3β phosphorylation and tau-mediated microtubule stabilization, affecting cell migration 3. In cancer contexts, DRG2 exhibits dual roles: it promotes melanoma growth and metastasis by enhancing VEGF-A expression 4, yet paradoxically, DRG2 knockdown sensitizes prostate cancer cells to docetaxel-induced apoptosis by disrupting G2/M cell cycle arrest 5. Additionally, DRG2 regulates PD-L1 surface localization through endosomal recycling, affecting anti-PD-1 immunotherapy efficacy 6. The protein also influences adipocyte differentiation in cooperation with PPAR-γ 7. DRG2 forms specific complexes with DFRP2, which enhances protein stability 8. Transcriptionally, DRG2 expression is regulated by Sp1 transcription factor 1.