RWDD1 (RWD domain containing 1) is an intrinsically unstructured protein with multifaceted cellular functions. Primarily, RWDD1 acts as a coactivator of the androgen receptor (AR) transcription factor, interacting with the AR ligand binding domain to enhance androgen-dependent transactivation 1. This function is particularly important during male genital development, where RWDD1 was identified as an AR-interacting protein in embryonic genital tissue 1. Beyond AR signaling, RWDD1 can function as a transcription factor itself, binding DNA promoter regions to regulate gene expression, as demonstrated in mitochondrial sulfide metabolism pathways 2. RWDD1 expression is dynamically regulated during aging and stress. Thymic RWDD1 expression decreases in aged and oxidatively stressed mice, suggesting a role in thymus involution and immune aging 3. Recent longevity studies identified RWDD1 as a strong candidate gene for human longevity, with long-lived individuals showing a statistically significant burden of rare missense variants, potentially involving mTOR signaling pathways 4. Clinically, RWDD1 expression associates with lithium adverse effects, particularly tremor and xerostomia, in psychiatric patients 5. Additionally, RWDD1 emerged as a candidate gene in obsessive-compulsive disorder pathogenesis through transcriptomic analysis 6.