DSCC1 (DNA replication and sister chr8 cohesion 1) functions as a critical regulator of DNA replication and genomic stability. As a component of the alternative replication factor C (RFC) complex, DSCC1 loads PCNA onto primed DNA templates, regulating replication fork velocity, spacing, and restart activity 1. The protein couples DNA replication to sister chr8 cohesion through regulation of SMC3 acetylation, with loss of DSCC1 causing severe genomic instability and micronucleus formation that can be rescued by SIRT1 loss through restoration of SMC3 protein acetylation 2. DSCC1 also plays a crucial role in DNA double-strand break repair pathway choice, where ATR-mediated phosphorylation recruits it to DSB sites during S/G2 phase to promote homologous recombination by restraining 53BP1/RIF1 signaling and facilitating DNA end resection 3. Clinically, DSCC1 is significantly overexpressed across multiple cancer types and correlates with poor prognosis, advanced tumor stages, and therapeutic resistance 45. In gastric cancer specifically, E2F4 transcriptionally activates DSCC1 to promote cell proliferation, migration, and invasion 6. The protein functions in parallel pathways with MMS22L-TONSL for sister chr8 cohesion establishment 7.