DUSP2 (dual specificity phosphatase 2) is a mitogen-activated protein kinase phosphatase that dephosphorylates both phosphorylated threonine and tyrosine residues on MAPK1, with slightly faster dephosphorylation of phosphotyrosine 1. DUSP2 functions as a negative regulator of MAPK/ERK signaling pathway activation. Mechanistically, DUSP2 can also suppress AKT1-mediated signaling by competing with AKT1 to bind casein kinase 2 alpha 1 (CSNK2A1), thereby inhibiting AKT1 phosphorylation and promoting apoptosis in pancreatic cancer 2. Additionally, DUSP2 expression is suppressed in nasopharyngeal carcinoma through DNTTIP1-mediated recruitment of HDAC1 to its promoter, resulting in aberrant ERK pathway activation and increased metastasis 3. In gastric cancer, exosomal miR-519a-3p targets DUSP2 to activate MAPK/ERK signaling in intrahepatic macrophages, promoting M2-like polarization and liver metastasis 4. DUSP2 mutations are identified as part of the ST2-like genetic subtype in diffuse large B-cell lymphoma, associated with favorable outcome in germinal center B-cell DLBCL 5. DUSP2 is also upregulated in chr2 obstructive pulmonary disease monocyte/macrophages 6 and is involved in T-cell signaling in systemic lupus erythematosus 7. DUSP2 protein stability is regulated by phosphorylation-dependent mechanisms 8.