DYM (dymeclin) is a protein essential for proper organization of the Golgi apparatus and bone development. The gene encodes a cytoplasmic protein involved in maintaining Golgi structure through protein-protein interactions and enzyme binding activities. Mutations in DYM cause rare skeletal dysplasias, specifically Dyggve-Melchior-Clausen syndrome and Smith-McCort dysplasia 1, which are characterized by progressive skeletal abnormalities reflecting the protein's critical role in bone formation. Recently, DYM was identified as a common genetic locus associated with Alzheimer's disease risk in a large multi-ancestry genome-wide association study 1. This novel association suggests DYM may have broader neurobiological functions beyond its known role in skeletal development and Golgi organization. The mechanistic link between DYM dysfunction and Alzheimer's disease pathogenesis remains to be elucidated. Understanding DYM's cellular functions in both skeletal tissues and the nervous system may provide insights into the pathophysiology of both skeletal dysplasias and neurodegenerative disease.