EHBP1 (EH domain binding protein 1) is a multifunctional adaptor protein that links vesicular trafficking to cytoskeletal regulation. The protein localizes to recycling endosomes and functions as a Rab effector, particularly RAB-10, to capture post-Golgi exocytic carriers through interactions involving its RAB-10-binding coiled-coil domain and PI(4,5)P2-binding C2 domain 1. EHBP1 is essential for insulin-regulated GLUT4 recycling in adipocytes, working with EHD1 to maintain perinuclear localization of GLUT4-containing membranes 2. Mechanistically, EHBP1 plays a critical role in cholesterol homeostasis by promoting sortilin-mediated PCSK9 secretion, which reduces LDL receptor levels and hepatic LDL uptake 3. Loss of EHBP1 impairs retromer complex localization, affecting intracellular protein sorting 3. The protein also participates in P2X7 purinergic signaling pathways controlling cell invasiveness through interactions with P-Rex1 4. Clinically, EHBP1 is a GWAS locus associated with LDL cholesterol levels and demonstrates disease relevance across multiple conditions. The rs721048 intronic variant associates with hereditary prostate cancer risk in Kazakh populations 5, while various EHBP1 SNPs (rs2710642, rs10496099, rs11688816) correlate with dyslipidemia in dialysis patients 6. Genetically predicted EHBP1 levels show causal associations with rheumatoid arthritis and potential utility as a therapeutic target 7. EHBP1 also suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis by regulating cholesterol metabolism 3.