EHBP1L1 (EH domain binding protein 1 like 1) functions as a Rab effector protein that coordinates vesicle trafficking and membrane transport. Mechanistically, EHBP1L1 directly binds GTP-loaded Rab8 and links it to the Bin1-dynamin complex at the endocytic recycling compartment (ERC), generating membrane curvature to excise vesicles for apical transport in polarized epithelial cells 1. The protein also mediates Rab10-dependent endosomal recycling and regulates macropinosome cargo turnover in immune cells 2, and stabilizes lysosomes through recruitment of Rab8/10 effectors during cellular stress 3. EHBP1L1 has significant disease relevance: dysregulation is implicated in acute coronary syndrome pathogenesis, with hypomethylation of EHBP1L1 promoter regions associated with increased expression in leukocytes and atheroma plaques, and causally linked to ACS risk 4. In renal cell carcinoma, EHBP1L1 overexpression drives immune evasion by stabilizing JAK1 protein, preventing its proteasomal degradation and elevating JAK1/STAT1/PD-L1 signaling, which suppresses CD8+ T cell-mediated antitumor immunity and confers resistance to immune checkpoint blockade 5. Loss-of-function mutations cause severe phenotypes including dyserythropoietic anemia and centronuclear myopathy in dogs 6, expanding the known spectrum of EHBP1L1-associated human genetic diseases.