ELP6 is a structural subunit of the Elongator complex, a highly conserved multiprotein assembly essential for multiple cellular functions 1. As part of the accessory Elp456 subcomplex, ELP6 acts as a bridge protein assembling Elp4 and Elp5 2 and contributes to the complex's ATP-modulated tRNA binding activity 3. ELP6 is required for Elongator-mediated tRNA modifications, including mcm5U, mcm5s2U, and ncm5U at the wobble position 34 3, which regulate translation efficiency 4. The complex regulates transcriptional elongation through histone acetylation and coordinates multiple biological processes including cell migration and tumorigenicity 5. Clinically, ELP6 variants associate with neurodevelopmental disorders. Patient-derived ELP6 mutations impair tRNA modification activity in vitro and in cells, causing developmental delay, epilepsy, intellectual disability, and motor dysfunction 6. The Elp456 subcomplex shows functional divergence from the catalytic Elp123 subcomplex, affecting specific tRNA species and cell types during neurodevelopment 6. ELP6 is broadly expressed in developing and mature granulocytes and monocytes 7, supporting its role in hematopoietic development and immune function.