EMC6 is a core subunit of the endoplasmic reticulum membrane protein complex (EMC) that facilitates energy-independent insertion of newly synthesized membrane proteins into ER membranes 1. EMC6 forms an enclosed hydrophilic vestibule in cooperation with EMC3, creating a pathway for substrate insertion through local membrane thinning and positive charge distribution 1. Beyond its canonical membrane insertion role, EMC6 functions as a tumor suppressor across multiple cancers. In hepatocellular carcinoma, EMC6 loss promotes tumor progression through dysregulation of lipid metabolism via HSD17B13 2. EMC6 suppresses gastric cancer cell growth by inducing mitochondrial-mediated apoptosis through ERK1/2 inactivation and BCL-2 downregulation 34. In glioblastoma, EMC6 activates autophagy by inhibiting the PIK3CA/AKT/mTOR pathway, suppressing tumor growth 5. EMC6 also regulates autophagy in pancreatitis through APAF1 upregulation, contributing to acinar cell apoptosis 6. In photoreceptors, EMC6 is essential for rhodopsin localization and ciliogenesis, with deficiency causing progressive degeneration 7. These findings establish EMC6 as a multifunctional protein linking membrane protein biogenesis to cellular homeostasis and disease pathogenesis.