ENY2 is a multifunctional transcriptional regulator that coordinates gene expression through its integration into multiple protein complexes. As a component of the SAGA complex, ENY2 participates in histone H2B deubiquitination and transcription activation 1, working with ATXN7L3 to orchestrate activities of multiple deubiquitinating enzymes including USP22, USP27X, and USP51 1. ENY2 also functions within the TREX-2 complex to facilitate mRNA export from the nucleus through nuclear pores 2, though recent evidence suggests this is its primary dedicated function distinct from other TREX-2 components 3. ENY2 serves as an adapter molecule integrating transcription, mRNA processing, and nuclear export 4, and participates in nuclear receptor-mediated transactivation 5. Clinically, ENY2 is upregulated across multiple cancer types and functions as both a diagnostic and prognostic biomarker 6. ENY2 depletion induces nucleolar stress through NPM1 release, triggering p53-dependent and p53-independent tumor suppression pathways 7. These findings position ENY2 as a potential therapeutic target for cancer management, though its role in human cells requires further investigation 8.