EPB41L1 encodes protein 4.1N, a structural adaptor protein that functions to confer stability and plasticity to neuronal membranes through interactions with the spectrin-actin-based cytoskeleton, integral membrane channels, and membrane-associated guanylate kinases 1. The gene undergoes alternative polyadenylation and splicing to generate protein diversity, with expression occurring across multiple tissues 1. EPB41L1 plays critical roles in cell adhesion and migration 2. In kidney renal clear cell carcinoma (KIRC), EPB41L1 is downregulated, and reduced expression correlates with poor prognosis; the protein coordinates with amyloid beta precursor protein to regulate cancer cell adhesion, thereby promoting metastasis and tumor invasion 2. Similarly, in glioblastoma multiforme, miR-431-5p suppresses EPB41L1 expression, and this downregulation promotes cell proliferation, invasion, and migration while inhibiting apoptosis 3. In cervical cancer, EPB41L1 expression was identified as one of four predictive genes in a model for lymph node metastasis risk assessment, demonstrating superior diagnostic performance compared to conventional imaging 4. Germline deletions involving EPB41L1 at chromosome 20.2 are associated with intellectual developmental disorder, autosomal dominant 11, characterized by growth retardation, feeding difficulties, hypotonia, and psychomotor developmental delay 5. Genomic alterations including loss of heterozygosity of EPB41L1 have been identified in gastric adenocarcinoma and linked to peritoneal invasion 6.