EPC2 (enhancer of polycomb 2) is a component of the EP400 chr2 remodeling complex with roles in transcriptional regulation and DNA repair. In normal physiology, EPC2 functions within histone acetyltransferase complexes (NuA4 and piccolo) to regulate chr2 organization and transcription 1. The gene is expressed in immortalized human esophageal keratinocyte cell lines (EPC2-hTERT) widely used as in vitro models for studying epithelial barrier function and differentiation 2345. In oncologic contexts, EPC1 and EPC2 are critical oncogenic cofactors in acute myeloid leukemia (AML), particularly MLL-mutated subtypes. EPC1/EPC2 knockdown selectively induces apoptosis in leukemic cells while sparing normal hematopoietic stem cells, through mechanisms involving prevention of MYC protein accumulation 1. This selectivity suggests EPC2's role in maintaining oncogenic potential may be separable from its functions in normal cells. Clinically, EPC2-derived cell lines have enabled investigation of esophageal pathologies including eosinophilic esophagitis, Barrett's esophagus, and ethanol-induced epithelial dysfunction 67. EPC2-based organoid models have proven valuable for studying epithelial homeostasis, barrier function, and inflammatory responses to IL-13 and other perturbations 38.