ERGIC1 (endoplasmic reticulum-Golgi intermediate compartment 1) encodes a putative transmembrane protein that functions in vesicular transport between the endoplasmic reticulum and Golgi apparatus 1. The protein localizes to the ER-Golgi intermediate compartment and facilitates bidirectional transport processes. ERGIC1 appears to regulate cellular proliferation, particularly in cancer contexts, where its expression correlates with oncogene activity 2. In prostate cancer, ERGIC1 silencing specifically affects ERG oncogene-positive cells and reduces ERG mRNA expression 2. The gene also influences autophagy inhibition and interferon-gamma signaling through IFNGR1 stabilization, affecting MHC class I expression and immune surveillance 3. Disease associations include arthrogryposis multiplex congenita, where bi-allelic ERGIC1 loss causes relatively mild joint contractures and facial dysmorphism 1. Complete loss of function through homozygous deletion results in absence of ERGIC1 expression but produces a surprisingly mild arthrogryposis phenotype 1. ERGIC1 has also been identified as a susceptibility gene for amyotrophic lateral sclerosis through genome-wide association studies 4 and shows altered expression in gastric cancer progression 5.