ERGIC2 (ERGIC and golgi 2) is an endoplasmic reticulum (ER) resident protein that plays a critical role in bidirectional vesicle-mediated transport between the ER and Golgi apparatus 1. The protein functions as part of a heteromeric complex with ERGIC3, serving as a cargo receptor in both anterograde and retrograde protein trafficking pathways 2. ERGIC2 is essential for Golgi-to-ER retrograde recycling of proteins like WLS during Wnt secretion, working alongside COPI regulator ARF and contributing to efficient Wnt secretory function 1. The protein also facilitates retrograde trafficking of the KDEL receptor and certain toxins 1. ERGIC2 shows tissue-specific expression patterns and interactions, binding to otoferlin in brain tissue but not in cochlea, suggesting it forms different protein complexes depending on cellular context 3. The protein has been implicated in various disease processes, including prostate cancer where its expression is downregulated 4, and neurodevelopmental disorders where copy number variations in the ERGIC2 locus may contribute to intellectual disability 5. Additionally, ERGIC2 interacts with β-amyloid peptide and may play a role in cholesterol transport and metabolism pathways 6.