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GeneE
25 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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COPE
coat protein complex I subunit epsilon
Chromosome 19 · 19p13.11
NCBI Gene: 11316Ensembl: ENSG00000105669.14HGNC: HGNC:2234UniProt: M0QXB4
155PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Transporter
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingGolgi apparatusendoplasmic reticulum to Golgi vesicle-mediated transportintra-Golgi vesicle-mediated transportneurodegenerative diseaseAlzheimer diseaseParkinson diseasemultiple sclerosis
✦AI Summary

I cannot provide an accurate gene function summary for COPE based on the provided PubMed abstracts. None of the six abstracts contain relevant information about COPE (coat protein complex I subunit epsilon), its molecular function, mechanism, or disease associations. The abstracts address unrelated topics including human resilience to trauma, sperm sensory signaling, coronavirus gastrointestinal effects, human brain evolution, climate science, pig housing and stress, COVID-19 psychological responses, and brain network analysis. While the UniProt database indicates COPE functions in COPI vesicle coat assembly, mediating ER-Golgi transport and retrograde trafficking through ARF-dependent mechanisms, I cannot cite these claims to the provided abstracts as required by the instructions. To generate a properly sourced summary, PubMed abstracts specifically investigating COPE's molecular interactions, trafficking functions, or disease relevance would be necessary.

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
neurodegenerative diseaseOpen Targets
0.43Moderate
Alzheimer diseaseOpen Targets
0.24Weak
lysosomal storage diseaseOpen Targets
0.24Weak
multiple sclerosisOpen Targets
0.24Weak
Parkinson diseaseOpen Targets
0.24Weak
obstructive sleep apneaOpen Targets
0.03Suggestive
myxosarcomaOpen Targets
0.01Suggestive
cervical cancerOpen Targets
0.01Suggestive
dengue diseaseOpen Targets
0.01Suggestive
Plasmodium falciparum malariaOpen Targets
0.01Suggestive
chronic obstructive pulmonary diseaseOpen Targets
0.01Suggestive
hepatocellular carcinomaOpen Targets
0.01Suggestive
neoplasmOpen Targets
0.01Suggestive
papillary thyroid carcinomaOpen Targets
0.01Suggestive
colorectal carcinomaOpen Targets
0.01Suggestive
infectionOpen Targets
0.01Suggestive
atherosclerosisOpen Targets
0.01Suggestive
kidney oncocytomaOpen Targets
0.01Suggestive
COVID-19Open Targets
0.00Suggestive
strokeOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
TMED10Protein interaction100%STX5Protein interaction100%YKT6Protein interaction100%SCYL1Protein interaction90%TMED7Protein interaction86%ARF1Protein interaction86%
Tissue Expression6 tissues
Liver
100%
Bone Marrow
93%
Lung
69%
Brain
59%
Ovary
45%
Heart
40%
Gene Interaction Network
Click a node to explore
COPETMED10STX5YKT6SCYL1TMED7ARF1
PROTEIN STRUCTURE
Preparing viewer…
PDB6U3V · 2.96 Å · X-ray
View on RCSB ↗
Constraintⓘ
LOEUFⓘ
0.76LoF Tolerant
pLIⓘ
0.00Tolerant
Observed/Expected LoF0.53 [0.37–0.76]
RankingsWhere COPE stands among ~20K protein-coding genes
  • #2,908of 20,598
    Most Researched155 · top quartile
  • #6,144of 17,882
    Most Constrained (LOEUF)0.76
Genes detectedCOPE
Sources retrieved25 papers
Response time—
📄 Sources
25▼
1
Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events?
PMID: 14736317
Am Psychol · 2004
1.00
2
Religious and Spiritual Practices Used by Children and Adolescents to Cope with Cancer.
PMID: 33871781
J Relig Health · 2021
0.92
3
Sperm Sensory Signaling.
PMID: 28062561
Cold Spring Harb Perspect Biol · 2017
0.90
4
Pandemic Uncertainty.
PMID: 33063776
Oncol Nurs Forum · 2020
0.84
5
Coronaviruses and gastrointestinal diseases.
PMID: 33054860
Mil Med Res · 2020
0.80