ERGIC3 (ERGIC and golgi 3) is a type II transmembrane protein that plays a critical role in protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus 1. ERGIC3 functions as a cargo receptor in both anterograde and retrograde transport, forming complexes with ERGIC2 and binding to itself to facilitate vesicle transport 1. The protein positively regulates trafficking of specific secretory proteins, including SERPINA1/alpha1-antitrypsin and HP/haptoglobin, with ERGIC3 depletion significantly decreasing their secretion 1. ERGIC3 expression is regulated by the E3 ubiquitin ligase MARCH2, which directs its ubiquitination and degradation at lysine residues 6 and 8, and by miR-203a downregulation 12. In disease contexts, ERGIC3 is overexpressed in various cancers, particularly non-small cell lung cancer, where it correlates with poor prognosis and enhanced cancer cell growth 324. ERGIC3 knockdown induces ER stress-mediated autophagic cell death and suppresses tumor growth, making it a potential therapeutic target 35. The protein also contributes to cellular oxidative stress regulation through interactions with palmitoylation machinery 6.