ERLEC1 (endoplasmic reticulum lectin 1) functions as a quality control protein in the endoplasmic reticulum (ER), where it likely binds to misfolded proteins and participates in ER-associated degradation (ERAD) pathways. The protein demonstrates high selectivity as a substrate for cotranslational translocation inhibition, with studies showing ERLEC1 expression is affected by the ER translocation inhibitor CADA, though with lower sensitivity compared to other substrates 1. ERLEC1 plays a role in cellular stress responses, particularly ER stress, as evidenced by its differential expression in various pathological conditions 2 3 4. In osteoblast biology, ERLEC1 inhibits cell proliferation and is crucial for proper osteogenic differentiation, with pathogenic variants associated with Class III malocclusion in humans 5. The gene shows disease relevance across multiple conditions, serving as a potential biomarker for periodontitis 2 4, and displaying altered expression in pancreatic alpha cells from type 1 diabetes patients 3. Additionally, ERLEC1 splice variants have been associated with psychiatric disorders, particularly schizophrenia risk 6, and the protein shows positive associations with cognitive performance measures 7.