EXOSC6 is a non-catalytic structural component of the RNA exosome complex, a ribonuclease responsible for 3'→5' exoribonucleolytic activity and RNA processing 1. As part of the exosome's catalytically inactive core (Exo-9), EXOSC6 functions as a molecular scaffold for binding and presenting RNA substrates for degradation, facilitating nuclear maturation of stable RNAs (rRNA, snRNA, snoRNA) and elimination of defective transcripts, while also participating in cytoplasmic mRNA turnover and surveillance pathways 2. Disease relevance spans multiple cancer types: EXOSC6 peptide epitopes are uniquely presented on breast cancer cell surfaces and recognized by CD8+ T cells 1, while the gene appears dysregulated in colon adenocarcinoma tissues and represents a novel biomarker candidate 3. EXOSC6 is also incorporated into endoplasmic reticulum stress-related prognostic signatures for head and neck squamous cell carcinoma, correlating with immune infiltration patterns and immunotherapy response prediction 4. Additionally, genetic variants in EXOSC6 associate with facial aging susceptibility in multi-omics analyses 5, and hyperthermia treatment downregulates EXOSC6 expression in HPV-infected condyloma acuminata tissues, potentially compromising viral infectivity through metabolic disruption 2.