EXOSC7 is a non-catalytic core component of the RNA exosome complex, a conserved 3'→5' exoribonuclease machinery essential for RNA processing and degradation across cellular compartments 1. In the nucleus, EXOSC7 participates in maturation of stable RNAs (rRNA, snRNA, snoRNA) and elimination of aberrant transcripts, including antisense RNAs and defective mRNAs destined for cytoplasmic export 2. Cytoplasmic EXOSC7 contributes to mRNA turnover, particularly degradation of AU-rich element-containing transcripts and RNA surveillance pathways preventing translation of aberrant mRNAs 2. EXOSC7 functions as part of the catalytically inactive 9-subunit exosomal core (Exo-9), which serves as a scaffold for binding catalytic subunits and accessory proteins 1. Clinically, EXOSC7 variants cause rare genetic diseases termed exosomopathies, with disease mechanisms including both reduced protein expression and functional defects 1. EXOSC7 dysregulation is associated with multiple pathological conditions: reduced expression in gestational diabetes placental tissues 3, genomic loss in cervical squamous cell carcinoma 4, and altered plasma peptide levels in Alzheimer's disease 5. These disease associations suggest EXOSC7's broader importance in cellular homeostasis beyond its canonical RNA exosome functions.