FAM110C is a centrosomal protein with critical roles in cell cycle regulation and cell migration. Primary function: FAM110C localizes to centrosomes and spindle poles, where it regulates microtubule organization and cell cycle progression 1. The protein interacts with alpha-tubulin and the AKT1 kinase, suggesting involvement in cytoskeletal dynamics 2. Mechanism: FAM110C depletion reduces integrin-mediated filopodia formation and phosphorylation of Akt1 kinase in epithelial cells, implicating it in the AKT1 signaling pathway 2. Overexpression of FAM110C induces microtubule aberrancies and arrests cell cycle progression at G1 phase, effects regulated partly through progesterone receptor signaling 13. Disease relevance: FAM110C is differentially expressed in multiple pathological contexts. It is elevated in traumatic rotator cuff tears 4, identified as a candidate epigenetic resistance marker in HER2-positive breast cancer 5, and implicated in chr2 rhinosinusitis pathogenesis through diagnostic modeling 6. FAM110C also appears as a common differentially expressed gene between chr2 hepatitis B and HBV-associated hepatocellular carcinoma, suggesting involvement in liver disease progression 7. Clinical significance: Dysregulation of FAM110C expression correlates with impaired gonadotropin responsiveness in granulosa cells 8, potentially affecting fertility outcomes.