FAM161B is a centrosomal protein involved in cilium organization and microtubule cytoskeleton regulation. As a paralog of FAM161A, FAM161B shares a conserved UPF0564 domain that mediates protein-protein interactions and microtubule binding 1. FAM161B physically interacts with TACC3, a centrosomal protein complex component, and co-localizes at spindle poles and cytokinetic bridges during cell division 2. The FAM161 protein family functions in ciliary structure and function; FAM161A localizes to the connecting cilium and basal body, interacting with ciliopathy-associated proteins including CEP290, OFD1, and SDCCAG8 3. FAM161A promotes microtubule stabilization and acetylation through its conserved domain, essential for ciliary assembly and maintenance 1. Disease relevance includes retinitis pigmentosa (RP28), a retinal ciliopathy caused by FAM161A mutations 3, and potential involvement in colon cancer development, where FAM161B expression is regulated by DNA methylation and reduced in tumorous compared to normal tissues 4. Given FAM161B's structural and functional conservation with FAM161A, it likely contributes to ciliary organization and microtubule dynamics, though its specific retinal and cancer roles require further characterization.