TTC17 (tetratricopeptide repeat domain 17) is a tetratricopeptide repeat-containing protein that plays crucial roles in both ciliogenesis and protein trafficking within the secretory pathway. The protein localizes to the endoplasmic reticulum and functions as an adaptor protein, interacting with various chaperones and cochaperones involved in protein folding, quality control, and maturation processes 1. TTC17 modulates actin polymerization and is essential for primary ciliogenesis, working in conjunction with C2orf62 to regulate these processes 2. Loss of TTC17 function disrupts actin organization, reduces primary cilia formation, and causes defects in Golgi polarization leading to glycosylation abnormalities 23. Clinically, TTC17 variants are associated with biliary atresia, particularly in patients with laterality defects, supporting its role as a ciliopathy gene 4. Additionally, homozygous mutations in TTC17 cause oligoteratoasthenozoospermia, a male infertility condition characterized by poor sperm quality, quantity, and motility, with affected sperm showing axoneme abnormalities and disrupted F-actin distribution 5. The protein's upregulation during ER stress and its interaction with secretory pathway components highlight its importance in maintaining cellular homeostasis 1.