FAM185A is a nuclear-encoded gene localized to chromosome 7 with predicted mitochondrial function based on GO annotations indicating mitochondrion localization and protein binding capacity. While its precise molecular function remains incompletely characterized, FAM185A has been identified as a nuclear-encoded mitochondrial variant associated with exercise response phenotypes. Specifically, the rs113400963 SNP in FAM185A was found to be significantly associated with high-intensity interval training outcomes in a genome-wide analysis of mitochondrial and nuclear-encoded mitochondrial genes 1. This suggests FAM185A may participate in mitochondrial energy metabolism or adaptive responses to exercise stress. In disease contexts, FAM185A was identified as one of 12 genes differentially expressed between immunologically "hot" and "cold" colorectal tumors, indicating potential involvement in tumor immune microenvironment regulation 2. Additionally, FAM185A was identified as a transcription factor in thymoma dysfunction modules associated with immune-related biological functions, including neutrophil-mediated immunity 3. Collectively, these findings suggest FAM185A may function in mitochondrial processes and immune regulation, though direct functional validation and mechanistic studies are needed to establish its precise role in these biological processes.