PEX13 is a peroxisomal membrane protein that functions as a critical component of the peroxisomal import machinery. It forms part of the PEX13-PEX14 docking complex, which acts as a selective translocon channel mediating the import of cargo proteins into peroxisomes 1. PEX13 contains a conserved tyrosine- and glycine-rich (YG) domain that forms a hydrogel-like selective phase resembling nuclear pore phenylalanine-glycine repeats, creating an aqueous conduit through which the PEX5 receptor transports folded cargo proteins across the peroxisomal membrane 12. This YG meshwork architecture enables selective partitioning of PEX5 and efficient protein translocation for both PTS1- and PTS2-type targeting sequences 2. Beyond its canonical import function, PEX13 serves a quality control role by preventing pexophagy—selective autophagy-mediated peroxisome degradation—in healthy organelles. Loss of PEX13 causes accumulation of ubiquitinated PEX5 and elevated peroxisomal reactive oxygen species, triggering aberrant pexophagy 3. PEX13 protein levels are downregulated during cellular stress to permit pexophagy induction as part of normal peroxisome homeostasis 3. Mutations in PEX13 cause peroxisome biogenesis disorders (PBD-11A and 11B), leading to impaired peroxisomal metabolism and neurodegenerative complications 4.