Based on limited published evidence, FAM98C is a protein with sequence similarity to family members FAM98A and FAM98B. It localizes to the tRNA-splicing ligase complex and exhibits protein binding capability. FAM98C was identified as a novel candidate gene in ciliopathy patients, with mutations associated with ciliary disorders 1. Recent functional studies demonstrate that FAM98C knockdown attenuates osteoclastogenesis in osteoclast precursors, suggesting a role in bone cell differentiation 2. However, its precise molecular mechanisms and physiological functions remain largely unknown.