FCRLA (Fc receptor-like A) is an endoplasmic reticulum-resident protein expressed primarily in B cells, particularly in germinal centers, with restricted expression in plasmacytoid dendritic cells 1. Unlike classical Fc receptors, FCRLA lacks a transmembrane region and is not glycosylated, but shares structural homology with FcγRI 2. Its primary function involves intracellular association with multiple immunoglobulin isotypes (IgM, IgG, and IgA) 32, suggesting roles in immunoglobulin assembly and potentially acting as a decoy receptor to regulate B cell activation 2. However, FCRLA is dispensable for antigen-specific immune responses 4. Beyond B cell biology, FCRLA has emerged as a disease-relevant gene associated with idiopathic inflammatory myopathies 5 and cancer progression. In cutaneous malignant melanoma, TNFα activation of the PLEKHA5-FCRLA axis promotes lipid metabolism changes and malignant behavior 6. In lung adenocarcinoma, FCRLA knockdown induces mitochondrial permeability transition-driven necrosis by disrupting mitochondrial structure and membrane potential, representing a potential therapeutic target 7. These findings suggest FCRLA functions in both normal B cell development and aberrant pathways contributing to autoimmune and malignant disease.