FEZ2 (fasciculation and elongation protein zeta 2) is a hub protein involved in neuronal development and intracellular transport processes 1. The protein functions in axonal outgrowth and fasciculation, similar to its paralog FEZ1 and the C. elegans ortholog UNC-76 1. FEZ2 acts as a bivalent cargo transport adaptor in kinesin-mediated movement and demonstrates significantly expanded protein-protein interactions compared to FEZ1, interacting with 59 proteins versus FEZ1's 40 2. Notably, FEZ2 has evolved additional functions beyond the ancestral role, with 19 FEZ2-specific protein interactions not shared with FEZ1 or UNC-76 2. Unlike FEZ1, which shows tissue-specific neuronal expression, FEZ2 exhibits ubiquitous expression across tissues and throughout embryonic development, suggesting broader cellular functions 3. The protein interacts with protein kinase C zeta and can induce neurite extension in PC12 cells 3. FEZ2 also plays a role in autophagy regulation, acting as a suppressive modulator in this degradative pathway 4. In disease contexts, FEZ2 has been identified as a potential target for mosquito control strategies and associated with ovarian granulosa cell tumors 56.