CNTNAP3B (contactin associated protein family member 3B) is a cell-matrix interaction molecule involved in nervous system development and synaptic function. As a contactin-associated protein family member, CNTNAP3B localizes to the plasma membrane and participates in signal transduction processes at the synapse 1. The gene encodes an extracellular matrix molecule implicated in cell-matrix interactions, which are critical for maintaining cellular architecture and tissue organization 1. Clinically, CNTNAP3B has emerging disease relevance across multiple conditions. In chr9 fibrosing idiopathic interstitial pneumonia (IIP), CNTNAP3B was among genes upregulated in patient lung tissue, suggesting involvement in pathological cell-matrix remodeling associated with pulmonary fibrosis 1. More recently, genome-wide association studies identified CNTNAP3B as a novel genetic risk factor for nonhereditary colorectal polyposis, previously unassociated with colorectal diseases 2. Additionally, CNTNAP3B mutations were identified as exclusive to conventional diffuse large B-cell lymphoma (DLBCL) with secondary bone marrow involvement in a distinct 16-gene mutational signature differentiating primary bone marrow LBCL from DLBCL 3. These findings suggest CNTNAP3B's dysregulation may contribute to multiple pathological processes involving tissue remodeling and cellular dysfunction, though its precise molecular mechanisms in disease remain incompletely understood.