FGB (fibrinogen beta chain) encodes one of three polypeptide chains that form fibrinogen, a 340 kDa plasma glycoprotein essential for hemostasis 1. The FGB-derived Bβ chain, together with FGA and FGG chains, polymerizes into insoluble fibrin matrix following thrombin cleavage, serving as a primary component of blood clots 2. Beyond coagulation, fibrinogen functions in wound repair stabilization and cell migration during re-epithelialization, and enhances platelet activation 1. Fibrinogen levels are regulated by inflammatory cytokines and can increase up to 3-fold during acute inflammation 1. Mutations in FGB cause congenital fibrinogen disorders, including afibrinogenemia and dysfibrinogenemia, characterized by bleeding complications and, notably, thrombotic events (11% in afibrinogenemia) 2. FGB genetic polymorphisms (-148C>T and -455G/A) are associated with increased ischemic stroke and coronary artery disease risk, particularly in Asian populations [PMID:25867317; 36]. Maternal fibrinogen is essential for successful pregnancy, with dysfibrinogenemic women experiencing high spontaneous abortion rates (86%) 2. Understanding FGB regulation and mutation mechanisms offers potential therapeutic targets for modulating fibrinogen in bleeding, thrombotic, and inflammatory diseases.