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GeneE
10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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FGR
FGR proto-oncogene, Src family tyrosine kinase
Chromosome 1 · 1p35.3
NCBI Gene: 2268Ensembl: ENSG00000000938.14HGNC: HGNC:3697UniProt: P09769
114PubMed Papers
20Diseases
5Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
KinaseOncogene
CLINICAL
FDA Approved Target
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
phosphotyrosine residue bindingprotein autophosphorylationintegrin-mediated signaling pathwayFc-gamma receptor I complex bindingchronic myelogenous leukemiaacute lymphoblastic leukemiacutaneous Leishmaniasisneoplasm
✦AI Summary

Based on the provided abstracts, there is insufficient information to accurately summarize the function of the FGR gene (FGR proto-oncogene, Src family tyrosine kinase). The abstracts provided discuss fetal growth restriction (FGR) as a clinical condition and various molecular mechanisms involved in placental dysfunction, but they do not contain specific information about the FGR gene itself or its protein product. The abstracts focus on placental pathology, trophoblast function, and various signaling pathways involved in pregnancy complications, but none directly characterize the FGR proto-oncogene or its role as a Src family tyrosine kinase. To provide an accurate gene function summary, abstracts specifically addressing the FGR gene's molecular function, protein interactions, cellular localization, and biological roles would be required. The current literature provided discusses clinical FGR (the condition) rather than the FGR gene, making it impossible to ground any functional claims about this specific gene in the available evidence.

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
chronic myelogenous leukemiaOpen Targets
0.59Moderate
acute lymphoblastic leukemiaOpen Targets
0.53Moderate
cutaneous LeishmaniasisOpen Targets
0.46Moderate
neoplasmOpen Targets
0.42Moderate
lymphoid leukemiaOpen Targets
0.39Weak
Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 PositiveOpen Targets
0.39Weak
acute myeloid leukemiaOpen Targets
0.31Weak
leukemiaOpen Targets
0.30Weak
prostate adenocarcinomaOpen Targets
0.28Weak
obesityOpen Targets
0.19Weak
breast cancerOpen Targets
0.13Weak
MyoclonusOpen Targets
0.12Weak
prostate cancerOpen Targets
0.12Weak
non-small cell lung carcinomaOpen Targets
0.12Weak
cancerOpen Targets
0.11Weak
chronic lymphocytic leukemiaOpen Targets
0.11Weak
pancreatic carcinomaOpen Targets
0.10Weak
lung cancerOpen Targets
0.10Weak
melanomaOpen Targets
0.10Weak
multiple myelomaOpen Targets
0.10Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Drug Targets5
DASATINIB ANHYDROUSApproved
Bcr/Abl fusion protein inhibitor
acute lymphoblastic leukemia
ENMD-981693Phase II
Fibroblast growth factor receptor inhibitor
ILORASERTIBPhase II
Platelet-derived growth factor receptor inhibitor
TG100-801Phase II
Ephrin type-B receptor 4 inhibitor
macular degeneration
XL-228Phase I
Insulin-like growth factor I receptor inhibitor
childhood leukemia
Related Genes
ITKProtein interaction100%SYKProtein interaction100%PIK3CBProtein interaction100%PIK3CDProtein interaction100%PIK3CAProtein interaction100%PIK3CGProtein interaction100%
Tissue Expression6 tissues
Bone Marrow
100%
Lung
79%
Liver
6%
Heart
2%
Ovary
2%
Brain
1%
Gene Interaction Network
Click a node to explore
FGRITKSYKPIK3CBPIK3CDPIK3CAPIK3CG
PROTEIN STRUCTURE
Preparing viewer…
PDB7JT9 · 1.93 Å · X-ray
View on RCSB ↗
Constraintⓘ
LOEUFⓘ
0.56Moderately Constrained
pLIⓘ
0.50Tolerant
Observed/Expected LoF0.40 [0.29–0.56]
RankingsWhere FGR stands among ~20K protein-coding genes
  • #4,146of 20,598
    Most Researched114 · top quartile
  • #936of 1,025
    FDA-Approved Drug Targets1
  • #3,592of 17,882
    Most Constrained (LOEUF)0.56 · top quartile
Genes detectedFGR
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
The Placenta Regulates Intrauterine Fetal Growth via Exosomal PPARγ.
PMID: 39951006
Adv Sci (Weinh) · 2025
1.00
2
The RNA landscape of the human placenta in health and disease.
PMID: 33976128
Nat Commun · 2021
0.90
3
GLUT1 exacerbates trophoblast ferroptosis by modulating AMPK/ACC mediated lipid metabolism and promotes gestational diabetes mellitus associated fetal growth restriction.
PMID: 39707215
Mol Med · 2024
0.80
4
Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction.
PMID: 33377492
Hum Reprod Update · 2021
0.70
5
Melatonin protects against environmental stress-induced fetal growth restriction via suppressing ROS-mediated GCN2/ATF4/BNIP3-dependent mitophagy in placental trophoblasts.
PMID: 33454563
Redox Biol · 2021
0.60