SRMS (Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites) is a non-receptor tyrosine kinase that functions as a critical regulator of cellular signaling pathways 1. The enzyme phosphorylates multiple substrates including DOK1, KHDRBS1/SAM68, and VIM on tyrosine residues, with KHDRBS1 phosphorylation occurring in an EGF-dependent manner 23. SRMS also phosphorylates OTUB1, promoting deubiquitination of RPTOR and activating TORC1 signaling 4. Mechanistically, SRMS serves as a ROS sensor under platinum treatment, becoming activated by platinum-induced reactive oxygen species 5. Once activated, SRMS inhibits MKK4 kinase activity through direct phosphorylation at Y269 and Y307, subsequently attenuating MKK4-JNK signaling and reducing apoptosis 5. Clinically, SRMS plays a significant role in platinum resistance in ovarian cancer 5. Suppressing SRMS sensitizes p53-deficient ovarian cancer cells to platinum-based chemotherapy both in vitro and in vivo 5. The small molecule PLX4720, a B-RafV600E inhibitor, has been identified as a novel SRMS inhibitor capable of potentiating platinum efficacy and overcoming chemoresistance in ovarian cancer 5. Additionally, SRMS was identified as a hub gene in prognostic modeling for gastric cancer 6.