FKBPL (FKBP prolyl isomerase like) is a multifunctional protein with emerging roles in cellular homeostasis, vascular biology, and disease pathogenesis. Primary functions include regulation of endoplasmic reticulum (ER) quality control and angiogenesis. Mechanistically, FKBPL acts as a cytosolic ER-phagy regulator that interacts with the ER-resident protein CKAP4 to trigger ER fragmentation and selective autophagy of ER components 1. FKBPL also functions as an antiangiogenic protein 2 and protects endothelial cells from hypoxia-induced dysfunction by stabilizing hypoxia inducible factor-α 3. Additionally, FKBPL is regulated by miR-183-5p, and elevated FKBPL levels suppress vascular smooth muscle cell proliferation and migration while promoting autophagy 4. Disease relevance spans multiple pathologies. FKBPL expression is downregulated in diabetes-associated pregnancies, correlating with impaired placental angiogenesis and endothelial dysfunction 5. In breast cancer, low FKBPL levels predict worse breast cancer-specific survival 6. FKBPL also represents a potential therapeutic target in ankylosing spondylitis 7. Clinically, FKBPL and its therapeutic peptide AD-01 show promise for treating cardiovascular diseases and endothelial dysfunction, while FKBPL protein detection aids early-onset preeclampsia diagnosis 8.