FMNL2 (formin-like 2) is a diaphanous-related formin protein located on chromosome 2.3 that regulates cytoskeletal dynamics and cell morphology 1. As a formin homology protein containing FDD, FH1, and FH2 domains 1, FMNL2 nucleates and polymerizes actin filaments at the plasma membrane, with its N-terminal myristoylation targeting it to filopodia tips and C-terminal phosphorylation by PKCα regulating dynamic filopodia formation 2. FMNL2 also participates in cell-cell junction assembly, focal adhesion formation, and subcellular trafficking 3, and surprisingly localizes to exosomes, suggesting a novel role in extracellular vesicle assembly 3. In disease contexts, FMNL2 is highly expressed in metastatic colorectal cancer cells and directly promotes cancer cell invasion and metastasis 4. miR-34a suppresses colorectal cancer progression by targeting FMNL2, indicating its oncogenic role 5. In Alzheimer's disease, FMNL2 expression increases in response to amyloid toxicity and cerebrovascular pathology, promoting astroglia detachment from blood vessels and disrupting gliovascular interactions that normally facilitate amyloid-tau clearance 6. Thus FMNL2 represents a therapeutic target linking cytoskeletal regulation to both cancer metastasis and neurodegeneration.