FOXM1 (forkhead box M1) is an oncogenic transcription factor that plays critical roles in cell cycle regulation and cancer progression. As a transcription factor, FOXM1 regulates the expression of genes essential for cell proliferation, cell cycle progression, and DNA replication 1. FOXM1 functions through multiple mechanisms, including binding to promoter regions of target genes such as Lin28a to increase neural progenitor cell proliferation 2, and regulating m6A modification by binding to the IGF2BP3 promoter while affecting glycolysis through transcriptional activation of HK2 and PKM 3. In neuroblastoma cells, FOXM1 promotes proliferation and inhibits apoptosis through activation of the PI3K/AKT pathway 4. FOXM1 is overexpressed in the majority of human cancers and correlates with poor prognosis across multiple tumor types 5. Its upregulation is associated with enhanced cancer cell growth, metastasis, chemotherapy resistance, and modulation of the tumor immune microenvironment 16. The protein also influences immune cell infiltration patterns, with high FOXM1 expression linked to increased T follicular helper cell infiltration in hepatocellular carcinoma 3. These findings establish FOXM1 as a promising therapeutic target for cancer treatment 7.