CEP55 (centrosomal protein 55) is a multifunctional protein that plays critical roles in cell division and cancer progression. During cytokinesis, CEP55 functions at the midbody to facilitate the final separation of daughter cells, representing its primary cellular function 1. Beyond cytokinesis, CEP55 has emerged as a significant oncogenic factor across multiple cancer types. The protein is consistently overexpressed in various malignancies including lung, pancreatic, bladder, and acral melanoma, where high expression correlates with tumor aggressiveness, metastasis, and poor patient prognosis 1234. Mechanistically, CEP55 promotes tumorigenesis through activation of key signaling pathways, particularly the PI3K/AKT/mTOR pathway in pancreatic neuroendocrine neoplasms and MAPK signaling in melanoma 54. The protein can be transferred between cells via exosomes through an Alix-mediated mechanism involving secretory CD63-positive endosomes 6. Functionally, CEP55 knockdown consistently inhibits cancer cell proliferation, migration, and invasion while inducing apoptosis 27. These findings establish CEP55 as both a valuable diagnostic biomarker and potential therapeutic target across multiple cancer types.